To evaluate the antidiabetic activity of ethyl acetate and methanolic extracts of Bridelia retusa Spreng. bark on alloxan-induced diabetic rats. Diabetes was induced by a single dose of alloxan monohydrate (120 mg/kg i.p). The acute and chronic study included the measurement of blood glucose level at 0, 1, 3, 5, 7, 24 hrs and on 15th day after administration of extracts. Glibenclamide was used as a standard (5 mg/kg orally). Ethyl acetate and methanolic extracts showed more significant (**P<0.001) reduction in blood glucose level when compared with diabetic control. Similarly, it exhibited significant decrease in total cholesterol, triglycerides, transaminase, alkaline phosphatase and urea level and increases the serum insulin level in alloxan induced diabetic rats. An oral glucose tolerance test showed significant improvement in glucose tolerance in the animals treated with ethyl acetate and methanolic extracts. Histopathological estimation of pancrease showed regeneration of β-cells. The results obtained were compared with reference standard drug glibenclamide. The present study concluded that, the Bridelia retusa is an effective herb against alloxan-induced diabetes and also in preventing the metabolic alteration induced as the consequence of diabetes.
Loading....